| Title: | Analytical Practice & Protocol |
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| Long Title: | Analytical Practice & Protocol |
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| Field of Study: |
Analytical Chemistry
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| Valid From: |
Semester 1 - 2019/20 ( September 2019 ) |
| Module Coordinator: |
Donagh OMahony |
| Module Author: |
Nikolay Petkov |
| Module Description: |
This module further develops the theory and practice of analytical chemistry, with specific reference to the areas of spectroscopic and chromatographic instruments, protocols and applications. |
| Learning Outcomes |
| On successful completion of this module the learner will be able to: |
| LO1 |
Solve quantitative analytical problems based on analytical data using established calibration techniques. |
| LO2 |
Explain techniques used for sampling, sample pre-treatment and data analysis as part of the total analytical process. |
| LO3 |
Discuss (compare and contrast) operation principles and instrumentation of selected spectroscopic and chromatographic methods associated with modern instrumental analysis. |
| LO4 |
Appraise the application of spectroscopic and chromatographic analytical practices in pharmaceutical and biopharmaceutical manufacturing. |
| Pre-requisite learning |
Module Recommendations
This is prior learning (or a practical skill) that is strongly recommended before enrolment in this module. You may enrol in this module if you have not acquired the recommended learning but you will have considerable difficulty in passing (i.e. achieving the learning outcomes of) the module. While the prior learning is expressed as named CIT module(s) it also allows for learning (in another module or modules) which is equivalent to the learning specified in the named module(s). |
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Incompatible Modules
These are modules which have learning outcomes that are too similar to the learning outcomes of this module. You may not earn additional credit for the same learning and therefore you may not enrol in this module if you have successfully completed any modules in the incompatible list. |
| No incompatible modules listed |
Co-requisite Modules
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| No Co-requisite modules listed |
Requirements
This is prior learning (or a practical skill) that is mandatory before enrolment in this module is allowed. You may not enrol on this module if you have not acquired the learning specified in this section.
|
| No requirements listed |
Module Content & Assessment
| Indicative Content |
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Total analytical process
Sampling, sample pre-treatment and separation techniques. Standard addition and internal standard methods of quantitation. Types of error in analysis. Statistical evaluation of analytical data. Analytical calculations based on spectroscopic or chromatographic data.
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Spectroscopy
Holistic evaluation of atomic and molecular abrsorption and emsssion spectroscopy instrumentation: sources of radiation, optical system and detection. Detailed description of thermal and ICP atomic absorption, X-ray and optical fluorescence spectroscopies.
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Chromatography
Assessment and optimisation of parameters for LC and GC. LC normal and reverse approaches. Gas chromatography with non-mass dependant and MS detectors (CI and EI). LC hyphenated with magnetic sector-MS. Electrophoresis. Preparative Chromatography.
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Analytical practices in pharmaceutical manufacturing
Compare and contrast spectroscopic and chromatographic methods. Best practices, interference and chemical derivatisations used in pharmaceutical analysis. Time, cost, applicability to on-line quality control, limitations.
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| Assessment Breakdown | % |
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| Course Work | 40.00% |
| End of Module Formal Examination | 60.00% |
| Course Work |
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| Assessment Type |
Assessment Description |
Outcome addressed |
% of total |
Assessment Date |
| Short Answer Questions |
Theory test including topics such as sampling, pre-treatments, calibration, data analysis. |
1,2 |
15.0 |
Week 5 |
| Short Answer Questions |
Theory test including topics such as sources of radiation, optical systems, chromatrography columns and detectors (compare and contrast). |
3 |
15.0 |
Week 9 |
| Presentation |
Presentation on application of spectroscopy and chromatography methods in pharmaceutical and biopharmaceutical analysis |
4 |
10.0 |
Week 10 |
| End of Module Formal Examination |
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| Assessment Type |
Assessment Description |
Outcome addressed |
% of total |
Assessment Date |
| Formal Exam |
End-of-Semester Final Examination |
1,2,3,4 |
60.0 |
End-of-Semester |
| Reassessment Requirement |
Repeat examination
Reassessment of this module will consist of a repeat examination. It is possible that there will also be a requirement to be reassessed in a coursework element.
|
The institute reserves the right to alter the nature and timings of assessment
Module Workload
| Workload: Full Time |
| Workload Type |
Workload Description |
Hours |
Frequency |
Average Weekly Learner Workload |
| Lecture |
Module Content delivery |
4.0 |
Every Week |
4.00 |
| Independent & Directed Learning (Non-contact) |
Student undertakes independent study |
3.0 |
Every Week |
3.00 |
| Total Hours |
7.00 |
| Total Weekly Learner Workload |
7.00 |
| Total Weekly Contact Hours |
4.00 |
| Workload: Part Time |
| Workload Type |
Workload Description |
Hours |
Frequency |
Average Weekly Learner Workload |
| Lecture |
Module Content delivery |
4.0 |
Every Week |
4.00 |
| Independent & Directed Learning (Non-contact) |
Student undertakes independent study |
3.0 |
Every Week |
3.00 |
| Total Hours |
7.00 |
| Total Weekly Learner Workload |
7.00 |
| Total Weekly Contact Hours |
4.00 |
Module Resources
| Recommended Book Resources |
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- Douglas A. Skoog... [et al.] 2013, Fundamentals of Analytical Chemistry, 9th Ed., Chapters: 6,7,8,27,28, Cengage Learning, Inc CA, United States [ISBN: 9780495558286]
| | Supplementary Book Resources |
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- Anette Muellertz, Yvonne Perrie, Thomas Rades 2016, Analytical Techniques in the Pharmaceutical Sciences, 1st Ed., Spirnger [ISBN: 9781493940271]
- Elsa Lundanes, Leon Reubsaet, Tyge Greibrokk 2013, Basic Principles, Sample Preparations and Related Methods, 1 Ed., John Wiley & Sons Ltd. United Kingdom [ISBN: 3527336206]
| | Recommended Article/Paper Resources |
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- Institute of Validation Technology Step-by-Step Analytical Methods Validation and Protocol in the Quality System Compliance Industry
| | Supplementary Article/Paper Resources |
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- U.S. Department of Health and Human Services Food and Drug Administratio 2015, Analytical Procedures and Methods Validation for Drugs and Biologics
| | This module does not have any other resources |
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Module Delivered in
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