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CHEP7001 - Bioreactor Design

Title:Bioreactor Design
Long Title:Bioreactor Design
Module Code:CHEP7001
Duration:1 Semester
Credits: 5
NFQ Level:Advanced
Field of Study: Chemical & Process Eng
Valid From: Semester 1 - 2016/17 ( September 2016 )
Module Delivered in 1 programme(s)
Module Coordinator: NIALL MORRIS
Module Author: IAN O SULLIVAN
Module Description: This module studies the important principles and techniques that are used in the design and analysis of bioprocesses. It will also develop students' knowledge and understanding of industrial processing, analytical abilities and problem solving methodologies in this area. This module pays particular attention to the more 'traditional' bioprocesses.
Learning Outcomes
On successful completion of this module the learner will be able to:
LO1 Estimate values for process variables using suitable correlations and equations developed from first principles.
LO2 Formulate material and energy balances about batch,fed batch and continuously fed bioreactor systems.
LO3 Design bioreactor mass and heat transfer systems.
LO4 Model growth, substrate and product concentrations in bioreactor systems.
LO5 Formulate sensitivity analysis on bioreactor systems and determine optimum operating parameters.
Pre-requisite learning
Module Recommendations
This is prior learning (or a practical skill) that is strongly recommended before enrolment in this module. You may enrol in this module if you have not acquired the recommended learning but you will have considerable difficulty in passing (i.e. achieving the learning outcomes of) the module. While the prior learning is expressed as named CIT module(s) it also allows for learning (in another module or modules) which is equivalent to the learning specified in the named module(s).
1512 BIOL6001 Anatomy Cells/Tissues
Incompatible Modules
These are modules which have learning outcomes that are too similar to the learning outcomes of this module. You may not earn additional credit for the same learning and therefore you may not enrol in this module if you have successfully completed any modules in the incompatible list.
No incompatible modules listed
Co-requisite Modules
No Co-requisite modules listed

This is prior learning (or a practical skill) that is mandatory before enrolment in this module is allowed. You may not enrol on this module if you have not acquired the learning specified in this section.

No requirements listed

Module Content & Assessment

Indicative Content
Bioreactors and bioprocesses
Description of traditional bioprocesses and biopharmaceutical processes and associated design criteria. Overview of reactor types, materials of construction, sterilization, instrumentation, scale up and feeding regimes.
Kinetic parameter determination in microbial and enzymatic systems
Determination of kinetic parameters such as growth rate, saturation constant, endogenous metabolism coefficient, yield coefficient, rate of production, rate parameters, inhibition coefficients and velocity constants, the effect of environmental conditions on microbial and enzymatic kinetics.
Modelling batch, fed batch and continuous culture systems
Mass balances on batch, fed batch and continuous systems and the prediction of cell, substrate and product concentrations (as a function of time in batch and fed-batch systems).
Mass and heat transfer system design
Oxygen requirements, determination of kLa, rheology, agitator power requirements, system heat generation and removal.
Assessment Breakdown%
Course Work100.00%
Course Work
Assessment Type Assessment Description Outcome addressed % of total Assessment Date
Written Report Group report on an assigned bio-product. To include at a minimum a research paper review, selection of reactor type, details of ideal reactor conditions, organism kinetics and a material and energy balance. 1,4 30.0 Week 6
Project Group project on an assigned bio-product. Incorporating the design of the mass and heat transfer elements and modelling of substrate, biomass and product levels. 1,2,3,4,5 50.0 Week 13
Written Report Individual discussion on findings from both group reports to include a discussion on the optimum bioreactor configuration. 3,4,5 20.0 Sem End
No End of Module Formal Examination
Reassessment Requirement
Coursework Only
This module is reassessed solely on the basis of re-submitted coursework. There is no repeat written examination.

The institute reserves the right to alter the nature and timings of assessment


Module Workload

Workload: Full Time
Workload Type Workload Description Hours Frequency Average Weekly Learner Workload
Lecture Lecture 4.0 Every Week 4.00
Independent & Directed Learning (Non-contact) Independent Learning 3.0 Every Week 3.00
Total Hours 7.00
Total Weekly Learner Workload 7.00
Total Weekly Contact Hours 4.00
Workload: Part Time
Workload Type Workload Description Hours Frequency Average Weekly Learner Workload
Lecture Lecture 4.0 Every Week 4.00
Independent & Directed Learning (Non-contact) Independent Learning 3.0 Every Week 3.00
Total Hours 7.00
Total Weekly Learner Workload 7.00
Total Weekly Contact Hours 4.00

Module Resources

Recommended Book Resources
  • Pauline M. Doran 2012, Bioprocess Engineering Principles, 2nd Ed., Academic Press London [ISBN: 978-0122208515]
  • Michael L. Shuler & Fikret Kargi 2002, Bioprocess Engineering: Basic Concepts, 2nd Ed., Prentice Hall New Jersey, USA [ISBN: 0-13-081908-5]
Supplementary Book Resources
  • Colin Ratledge & Bjorn Kristiansen 2006, Basic Biotechnology, 3rd Edition Ed., Cambridge University Press Cambridge, UK [ISBN: 0-521-54958-2]
  • James E. Bailey & David F. Ollis 1986, Biochemical Engineering Fundamentals, 2nd Ed., McGraw Hill Singapore [ISBN: 0-07-066601-6]
  • J.F. Richardson & D.G. Peacock 1994, Chemical Engineering Volume 3 (Chemical & Biochemical Reactors & Process Control), 3rd Ed., 5, Pergamon Oxford, UK [ISBN: 0-08-041003-0]
  • edited by Hans-Peter Schmauder; editor of the English edition: Michael Schweizer, translated by: Lilian M. Schweizer 1997, Methods in biotechnology, Taylor & Francis London [ISBN: 0748404309]
This module does not have any article/paper resources
This module does not have any other resources

Module Delivered in

Programme Code Programme Semester Delivery
CR_ECPEN_8 Bachelor of Engineering (Honours) in Chemical and Biopharmaceutical Engineering 5 Mandatory

Cork Institute of Technology
Rossa Avenue, Bishopstown, Cork

Tel: 021-4326100     Fax: 021-4545343
Email: help@cit.edu.ie